Nicotinamide Adenine Dinucleotide (NAD+)
NAD+
Nicotinamide Adenine Dinucleotide (NAD+)
Nicotinamide adenine dinucleotide, or NAD+, is a naturally occurring coenzyme found throughout the body. It plays an important role in cellular energy production, mitochondrial function, and cellular repair. Research has explored how supporting NAD+ levels may contribute to healthy aging, metabolic function, muscle performance, and cellular health.
NAD+ levels naturally decline with age. This decrease has been associated with changes in cellular energy production, mitochondrial function, DNA repair, inflammation, and other processes involved in aging.
NAD+ supplementation is most effective when incorporated into a structured protocol. Our program includes an 8-week progressive approach designed to support cellular energy and establish a sustainable maintenance level.
NAD+
Key Potential Outcomes & Benefits
Energy & Metabolic Function: NAD+ plays an important role in mitochondrial energy production and cellular metabolism. Supporting NAD+ levels may help promote healthy energy and metabolic function.
Cardiovascular Health: Research has explored the potential relationship between NAD+ support, blood pressure, arterial health, and cardiovascular function.
Cognitive & Brain Health: NAD+ is involved in cellular processes that support brain health. Research continues to examine its potential role in healthy cognitive function and age-related changes.
Cellular Repair & Healthy Aging: NAD+ contributes to cellular repair processes and supports pathways involved in DNA maintenance and healthy aging.
Metabolic Health: NAD+ precursors have been studied for their potential effects on metabolism, insulin sensitivity, and weight-related metabolic health.
Immune & Inflammatory Support: Research has also examined NAD+ and its relationship to inflammatory pathways and overall cellular immune function.
NAD+
References
[1] Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2021 Sep 28;150(4 Suppl):41S–48S.
[2] Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9:1286.
[3] Hawkins J, Idoine R, Kwon J, Shao A, Dunne E, Hawkins E, Dawson K, Nkrumah-Elie Y. Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen+ IV and NAD+ IV in healthy adults. 2024 Jan 11.
[4] Saville KM, Clark J, Wilk A, et al. NAD+-mediated regulation of mammalian base excision repair. DNA Repair (Amst). 2020;93:102930.
[5] Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
[6] Elhassan YS, Kluckova K, Fletcher RS, et al. Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures. Cell Rep. 2019;28:1717–1728.e6.
What Our Patients Are Saying
Here are a few experiences shared by our patients.